Description
Biochem/physiol Actions A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin （protein phosphatase 2B）. Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

Properties
assay ≥98% （TLC）
storage temp. 2-8°C

Safety
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 （US）, Gloves, respirator cartridge type N100 （US）, type P1 （EN143） respirator filter, type P3 （EN 143） respirator cartridges
Hazard Codes T
Risk Statements 45-60-22
Safety Statements 53-45
WGK Germany 3
RTECS GZ4120000

References
reference Donjerkovic, et al., Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium. Cell. Growth Differ. 10, 695-704, （1999）
  Mordvinov, et al., A human T-cell line with inducible production of interleukins 5 and 4. A model for studies of gene expression. J. Immunol. Methods 228, 163-168, （1999）
  Zaidan, et al., Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastiatal NMDA or forebrain ischemia in rats. J. Neurochem. 73, 2214-2217, （1999）
  Pritchard, D.E., et al., Cyclosporin A inhibits chromium（VI）-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells. Carcinogenesis 21, 2027-2033, （2000）
Merck Merck 13,2781

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