Description
Biochem/physiol Actions Phleomycin is a structurally related form of the antibiotic, bleomycin. Phleomycin blocks S-phase entry in the cell cycle. While phleomycin can damage DNA, like bleomycin, it is not used as an anticancer agent, but rather as a selection agent. The RAD6 DNA repair gene is essential for phleomycin resistance in mutant yeast.

Properties
form powder
color light blue
storage temp. 2-8°C

Safety
Personal Protective Equipment dust mask type N95 （US）, Eyeshields, Gloves
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
RTECS SY0525000

References
reference Robson, C.N., et al., Bleomycin and X-ray-hypersensitive Chinese hamster ovary cell mutants: genetic analysis and cross-resistance to neocarzinostatin. Mutat. Res. 193, 157-165, （1988） Abstract
  Povirk, L.F., et al., Copper（II）.bleomycin, iron（III）.bleomycin, and copper（II）.phleomycin: comparative study of deoxyribonucleic acid binding. Biochemistry 20, 665-671, （1981） Abstract
  Sleigh, M.J., and Grigg, G.W., Sulphydryl-mediated DNA breakage by phleomycin in Escherichia coli. Mutat. Res. 42, 181-190, （1977） Abstract
  He, C.H., et al., A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene. Can. J. Microbiol. 42, 1263-1266, （1996） Abstract

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